Epididymosomes: the black box of Darwin’s pangenesis?

نویسندگان

چکیده

Abstract Darwin, in the pangenesis theory, imagined particles, named as ‘gemmules’, which are released from all (‘pan’) cells of body. By cell–cell communication and also circulation through body, they finally reach germ to participate generation (‘genesis’) new individual. It has been shown that circulatory exosomes affected by environmental stressors can parental cells. Therefore, mirror his could interact with epididymosomes: epididymis-derived have a wide spectrum variation content size, very sensitive stressors, may be involved translating external information The protein RNA cargo would transferred epididymosomes sperm during maturation, then delivered embryo at fertilization inherited offspring. this study, we will briefly discuss Darwin’s theory its possible relation epididymosomes. We believed considered an attractive candidate for storage contents, changing epigenome next generations, allowing reappearance acquired characteristics ancestors. epididymosomes, black box pangenesis, unravel life history disclose historical events affect

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ژورنال

عنوان ژورنال: Molecular human reproduction

سال: 2021

ISSN: ['1360-9947', '1460-2407']

DOI: https://doi.org/10.1093/molehr/gaaa079